Abnormal wiring of the structural connectome in adults with ADHD

Abstract Current knowledge of white matter changes in large-scale brain networks adult attention deficit hyperactivity disorder (ADHD) is scarce. We collected diffusion-weighted magnetic resonance imaging data 40 adults with ADHD and 36 neurotypical controls used constrained spherical deconvolution based tractography to reconstruct whole-brain structural connectivity networks. network-based statistic (NBS) graph theoretical analysis investigate differences these between the control groups, as well associations symptoms assessed Adult Self-Report Scale or performance Conners Continuous Performance Test 2 (CPT-2). NBS revealed decreased group compared widespread unilateral networks, which included subcortical corticocortical structures encompassed dorsal ventral visual somatomotor systems. Furthermore, hypoconnectivity a predominantly left-frontal network was associated higher amount commission errors CPT-2. Graph did not reveal topological groups properties task performance. Our results suggest that abnormal wiring manifested intrahemispheric previously functional neuroimaging studies.